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Claudia K Derian Selected Research

RWJ 58259

2/2003Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates.
1/2003RWJ-58259: a selective antagonist of protease activated receptor-1.

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Claudia K Derian Research Topics

Disease

7Thrombosis (Thrombus)
03/2006 - 01/2003
5Inflammation (Inflammations)
04/2008 - 01/2003
2Edema (Dropsy)
03/2007 - 03/2007
2Neoplasms (Cancer)
04/2006 - 01/2003
2Atherosclerosis
06/2003 - 01/2003
1Lung Injury
09/2009
1Fibrosis (Cirrhosis)
09/2009
1Pulmonary Fibrosis (Fibrosing Alveolitis)
09/2009
1Fever (Fevers)
04/2008
1Systemic Inflammatory Response Syndrome (Sepsis Syndrome)
04/2008
1Sepsis (Septicemia)
04/2008
1Disseminated Intravascular Coagulation
04/2008
1Interstitial Cystitis (Interstitial Cystitis, Chronic)
03/2007
1Cystitis
03/2007
1Breast Neoplasms (Breast Cancer)
04/2006
1Peritonitis
05/2005
1Chronic Obstructive Pulmonary Disease (COPD)
05/2005
1Asthma (Bronchial Asthma)
05/2005
1Necrosis
05/2005
1Stroke (Strokes)
04/2004
1Vascular System Injuries
01/2003
1Pathologic Constriction (Stenosis)
01/2003

Drug/Important Bio-Agent (IBA)

4ThrombinFDA Link
03/2007 - 01/2003
3Peptide Hydrolases (Proteases)FDA Link
09/2009 - 02/2003
2Interleukin-1beta (Interleukin 1 beta)IBA
04/2008 - 05/2005
2Peptides (Polypeptides)IBA
03/2007 - 03/2007
2PAR-1 ReceptorIBA
03/2007 - 03/2006
2LigandsIBA
04/2006 - 06/2004
2Thrombin Receptors (Thrombin Receptor)IBA
06/2003 - 02/2003
2RWJ 58259IBA
02/2003 - 01/2003
1Factor X (Stuart Factor)IBA
09/2009
1Bleomycin (Blenoxane)FDA LinkGeneric
09/2009
1Sphingosine-1-Phosphate ReceptorsIBA
04/2008
1Thromboplastin (Tissue Factor)IBA
04/2008
1AnticoagulantsIBA
04/2008
1Cytokine Receptors (Cytokine Receptor)IBA
04/2008
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
04/2008
1Complementary DNA (cDNA)IBA
03/2007
1GTP-Binding Proteins (G-Protein)IBA
03/2007
1Proteinase-Activated ReceptorsIBA
03/2007
1Tryptases (Tryptase)IBA
03/2007
1Growth Factor ReceptorsIBA
04/2006
1Estrogens (Estrogen)FDA Link
04/2006
1LipidsIBA
04/2006
1Hormones (Hormone)IBA
04/2006
1SteroidsIBA
04/2006
1Phosphotransferases (Kinase)IBA
04/2006
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
04/2006
1sphingosine kinaseIBA
04/2006
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
05/2005
1GlycogenIBA
05/2005
1Cathepsin GIBA
05/2005
1Serine Proteases (Serine Protease)IBA
05/2005
1Interleukin-1alpha (Interleukin 1 alpha)IBA
05/2005
1Chymases (Chymase)IBA
05/2005
1Nitric Oxide (Nitrogen Monoxide)FDA Link
05/2005
1LipopolysaccharidesIBA
05/2005
1Epinephrine (Adrenaline)FDA LinkGeneric
06/2004
1CollagenIBA
06/2004
1ferric chlorideIBA
06/2004
1FibrinolysinFDA Link
04/2004
1PlasminogenIBA
04/2004
1Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA
03/2003
1Fibrinogen (Factor I)FDA Link
02/2003
1AntibodiesIBA
02/2003

Therapy/Procedure

2Intravesical Administration
03/2007 - 03/2007